Is 100 mg Of Testosterone Every Four Days Appropriate?

A man asks whether 100 mg of testosterone enanthate every four days is an appropriate TRT regimen. Dr. O’Connor says it may suit some men but could be excessive for others. He describes commonly using testosterone cypionate at 100 mg every five days in his practice, emphasizing that the dose must be evaluated individually.

He recommends maintaining a consistent regimen for approximately six weeks before assessing levels in this scenario. He explains that testosterone exposure initially builds toward steady state and that laboratory timing matters when interpreting the result.

For the questioner’s four-day schedule, Dr. O’Connor recommends testing immediately before the next injection to assess the trough, or lowest level in the dosing interval. This is the monitoring approach he describes in the video rather than a universal testing schedule for every testosterone formulation.

The discussion then turns to total testosterone, free testosterone, and sex hormone-binding globulin, or SHBG. Dr. O’Connor emphasizes that differences in binding proteins can affect the relationship between total and free testosterone, making an isolated total value insufficient in some clinical situations.

He also stresses evaluating symptoms between injections and monitoring broader health through the ABCDs™ framework. Red blood cells, cardiovascular health, and prostate considerations are part of the discussion. He closes by challenging the assumption that an established testosterone regimen must continually increase because of tolerance, citing his own long-term experience.